Screening for Anti-allergic and Anti-histaminic Activity of Extract of Momordica dioica, Myrica esculenta and Euphorbia hirta in Animal Models

In the present study, the effect of aqueous extract of Momordica dioica, aqueous extract of Myrica esculenta and ethanolic extract of Euphorbia hirta a lone and in combinat ion on h istamine induced bronchospasm in guinea p ig, milk induced leukocytosis and eosinophilia in mice and on antipruritic activity in mice was done. In the animal model o f h istamine induced bronchospasm , all plant showed significant protection against bronchospasm induced by histamine. In milk induced leukocytosis and eosinophilia model, all plants showed significant decrease in difference in no. of leucocytes and eosinophils count. In the antipruritic activity model of mice, all these plants showed significant reduction in pruritic activity. Thus these results suggest that MD, ME and EH may prove to be a potential therapeutic drug for treating allergic diseases and the result obtained in this study may be due to its antihistaminic, adaptogenic, antistress, and anti-inflammatory activities.